The Next Generation of Biomaterials Part 2

Fortoss® VITAL is the first resorbable synthetic graft material capable of directing cell activity to produce rapid bone formation.

A material’s surface properties are pivotal in initiating biological activity. Recent research1 has highlighted the significance of relative zeta potentials of bone and different biomaterials and their influence on protein adsorption. This work has demonstrated that the adsorption of specific extracellular matrix proteins onto biomaterial surfaces provides sites for integrin mediated osteoblast attachment.

Fortoss VITAL has been engineered with an optimum surface chemistry which harnesses proteins key to bone formation. The surface chemistry is achieved through a proprietary process and controlled using Zeta potential measurements (ZPC®)2. This charge has a significant effect on the in-vivo response, biological activity and bone formation3 and has been found to be “favourable to bone regeneration and osseointegration of dental implants”4.

Fortoss VITAL consists of a unique bi-phasic composition of calcium sulphate and beta tri-calcium phospate (ß-TCP).

Fortoss VITAL is applied as a mouldable setting putty which can be contoured to the defect site. The “macroporous ß-TCP acts as a lattice for ingrowth of woven bone, while the early resorption of calcium sulphate phase creates an interconnecting pore structure”5.

Fortoss VITAL “possesses osteogenic activity and can support new bone formation”6. The use of Fortoss VITAL “produces significantly more vital new bone and preserved bone dimensions compared with the use of ß-TCP alone”7.

For references please see our Website.


Click below to read a Case Study from Dr Anthony Bendkowski

Vital Case Study